Read Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Raphael Enoque Ferraz de Paiva

4.9/5 (16246 ratings)

Description:This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins. To get started finding Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, you are right to find our website which has a comprehensive collection of manuals listed.
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Pages: 184

Format: PDF, EPUB & Kindle Edition

Publisher: Springer

Release: 2018

ISBN: f6eesxz

Description: This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins. To get started finding Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.

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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

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