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Somatic Hypermutation in V-Regions

E. J. Steele
4.9/5 (21207 ratings)
Description:This book provides critical reviews regarding the process of somatic hypermutation in antibody V genes. Topics covered include the in vivo kinetics of antigen-driven somatic hypermutation in a number of well-studied systems in mice; the instability of lg genes in cultured cells; the key role played in vivo by germinal centers in providing the appropriate "mutational" microenvironment; the types of nucleotide sequence errors generated; the process of hypermutation in pre-arranged V regions expressed in transgenic mice; and a critical evaluation of the status of molecular models proposed to explain hypermutation. Other topics include a detailed review of data from hypervariable retroviral systems, as well as precise studies on the mutagenic potential of various DNA polymerases in vitro. The book will provide indispensable information for immunologists, geneticists, molecular biologists, biochemists, and cell biologists.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Somatic Hypermutation in V-Regions. To get started finding Somatic Hypermutation in V-Regions, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.
Pages
200
Format
PDF, EPUB & Kindle Edition
Publisher
CRC Press
Release
1991
ISBN
Tgg

Somatic Hypermutation in V-Regions

E. J. Steele
4.4/5 (1290744 ratings)
Description: This book provides critical reviews regarding the process of somatic hypermutation in antibody V genes. Topics covered include the in vivo kinetics of antigen-driven somatic hypermutation in a number of well-studied systems in mice; the instability of lg genes in cultured cells; the key role played in vivo by germinal centers in providing the appropriate "mutational" microenvironment; the types of nucleotide sequence errors generated; the process of hypermutation in pre-arranged V regions expressed in transgenic mice; and a critical evaluation of the status of molecular models proposed to explain hypermutation. Other topics include a detailed review of data from hypervariable retroviral systems, as well as precise studies on the mutagenic potential of various DNA polymerases in vitro. The book will provide indispensable information for immunologists, geneticists, molecular biologists, biochemists, and cell biologists.We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Somatic Hypermutation in V-Regions. To get started finding Somatic Hypermutation in V-Regions, you are right to find our website which has a comprehensive collection of manuals listed.
Our library is the biggest of these that have literally hundreds of thousands of different products represented.
Pages
200
Format
PDF, EPUB & Kindle Edition
Publisher
CRC Press
Release
1991
ISBN
Tgg

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